Leaky Gut, Causes and Cures
"Maldigestion, malabsorption, and abnormal gut flora and ecology are often found to be primary contributing factors not only to gastrointestinal disorders but also to a wide variety of chronic, systemic illnesses."
"Maldigestion, malabsorption, and abnormal gut flora and ecology are often found to be primary contributing factors not only to gastrointestinal disorders but also to a wide variety of chronic, systemic illnesses."
Hormone Testing
The major sex hormones are estradiol, progesterone and testosterone. The adrenal hormones are DHEA and cortisol. These hormones will give us important information about deficiencies, excesses and your daily patterns.
Estrogen
The three forms that are made by the body: estrone, estradiol and esriol. You may have menopausal symptoms like hot flashes, fatigue, hair loss, insomnia and memory loss. Pre-menopausal women may have cramps, PMS, fatigue, and irritability when estrogens are out of balance. Men may have low testosterone and or high estrogens due to diet and lifestyle causing their testosterone to turn into estrogens.
Proesterone
Proesterone balances estradiol’s effects. It is considered preventative for breast and prostate cancers, and osteoporosis. Low progesterone can cause depression, irritability, insomnia, inflammation in the body, irregular periods, tender breasts, PMS and benign prostate gland enlargement (BPH).
Testosterone
A hormone that is essential for both males and females. It functions in the body to help build things, such as muscle. Testosterone is needed for heart function, mood, focus, bone health, muscle strength, stamina and sex drive.
DHEA
An important adrenal gland hormone for energy production and blood sugar balance. DHEA is a precursor to other hormones, such as testosterone.
Cortisol
Your waking day hormone (highest in the morning and lowest at night). It is necessary for energy production, blood sugar metabolism, anti-inflammatory effects and stress response. There are four phases of adrenal fatigue determined by the pattern of the four saliva test times – morning, noon, evening and night. Your cortisol level is compared to the optimal range.
Neurotransmitter Testing
Neurotransmitters are the brain chemicals enhancing transmission of neuronal signals across a synapse. Neurotransmitters have a wide range of effects in the body. Some of these include energy levels, mental focus, emotional and pain responses. Neurotransmitters are the brain’s chemical messengers; they allow communication between the body’s glands, organs and muscles. Numerous clinical studies have shown that a lack of neurotransmitter function influences our health and well-being.
Conditions associated with neurotransmitter imbalance include fatigue, insomnia, ADD, ADHD, OCD, brain fog, anxiety, depression, addiction, and loss of appetite control.
Toxin Analysis
Every day we are exposed to hundreds of toxic chemicals through products like pharmaceuticals, pesticides, packaged foods, household products, and environmental pollution! As we have become more exposed to chemical-laden products and to toxic chemicals in food, air and water, we have been confronted with an accelerating rate of chronic illnesses like cancer, heart disease, chronic fatigue syndrome, chemical sensitivity, autism spectrum disorders, ADD/ADHD, autoimmune disorders, Parkinson’s disease and Alzheimer’s disease.
This powerful yet simple urine test runs chemical profile that screens for the presence of 172 different toxic chemicals including organophosphate pesticides, phthalates, benzene, xylene, vinyl chloride, pyrethroid insecticides, acrylamide, perchlorate, diphenyl phosphate, ethylene oxide, acrylonitrile, and more. This profile also includes Tiglylglycine (TG), a marker for mitochondrial disorders resulting from mutations of mitochondrial DNA. These mutations can be caused by exposure to toxic chemicals, infections, inflammation and nutritional deficiencies.
ENVIRONMENTAL POLLUTANTS TESTED
Phthalates
Perhaps the most widespread group of toxic chemicals found in our environment. Phthalates are commonly found in after shave lotions, aspirins, cosmetics, detergents, foods microwaved with plastic covers, oral pharmaceutical drugs, intravenous products prepared in plastic bags, hair sprays, insecticides, insect repellents, nail polish, nail polish remover, skin care products, adhesives, explosives, lacquer, janitorial products, perfumes, paper coatings, printing inks, safety glass and varnishes. Phthalates have been implicated in reproductive damage, depressed leukocyte function and cancer. Pthalates have also been found to impede blood coagulation, lower testosterone and alter sexual development in children. Low levels of pthalates can feminize the male brain of the fetus, where high levels can hyper-masculinize the developing male brain.
Vinyl Chloride
Vinyl chloride is an intermediate in the synthesis of several commercialized chemicals, including polyvinyl chloride (PVC). Exposure to vinyl chloride may cause central nervous system depression, nausea, headache, dizziness, liver damage, degenerative bone changes, thrombocytopenia, enlargement of the spleen and death.
Benzene
Benzene is an organic solvent that is widespread in the environment. Benzene is a by-product of all sources of combustion, including cigarette smoke. It is released by outgassing from synthetic materials and is a pollutant released by numerous industrial processes. Benzene is an extremely toxic chemical that is mutagenic and carcinogenic. High exposures to benzene cause symptoms of nausea, vomiting, dizziness, lack of coordination, central nervous system depression and death. It can also cause hematological abnormalities.
Pyrethrins
Pyrethrins are widely used as insecticides. Exposure during pregnancy doubles the likelihood of autism. Pyrethrins may affect neurological development, disrupt hormones, induce cancer, and suppress the immune system.
Xylenes
Xylenes (dimethylbenzenes) are solvents not only found in common products such as paints, lacquers, pesticides, cleaning fluids, fuel and exhaust fumes, but also in perfumes and insect repellents. Xylenes are oxidized in the liver and bound to glycine before eliminated in urine. High xylene levels may be due to the use of certain perfumes and insect repellents. High exposures to xylene create an increase in oxidative stress, causing symptoms such as nausea, vomiting, dizziness, central nervous system depression and death. Occupational exposure is often found in pathology laboratories where xylene is used for tissue processing.
Styrene
Styrene is used in the manufacturing of plastics, in building materials, and is found in car exhaust fumes. Polystyrene and is copolymers are widely used as food packaging materials. The ability of styrene monomer to leach from polystyrene packaging to food has been reported. Occupational exposure due to inhalation of large amounts of styrene adversely impacts the central nervous system, causes concentration problems, muscle weakness, tiredness and nausea, and irritates the mucous membranes of the eyes, nose and throat.
Organophosphates
Organophosphates are one of the most toxic groups of substances used throughout the world. They are often used as biochemical weapons and terrorist agents, but are most commonly used in pesticide formulations. Organophosphates are inhibitors of cholinesterase enzymes, leading to overstimulation of nerve cells, causing sweating, salivation, diarrhea, and abnormal behavior, including aggression and depression. Children exposed to organophosphates have more than twice the risk of developing pervasive development disorder (PDD), an autism spectrum disorder. A study done in the San Francisco Bay area found that in California agricultural areas, children born to mothers living within 500 meters of fields where organochlorine pesticides were used were more than 6 times more likely to develop autism than children whose mothers did not live near such fields. ASD risk increased with the poundage of organochlorines applied and decreased with distance from field sites. Maternal organophosphate exposure has been associated with various adverse outcomes including having shorter pregnancies and children with impaired reflexes.
MTBE and ETBE
MTBE and ETBE are gasoline additives use to improve octane ratings. Exposure to these compounds is most likely due to groundwater contamination, and inhalation or skin exposure to gasoline or its vapors and exhaust fumes. MTBE has been demonstrated to cause hepatic, kidney, and central nervous system toxicity, peripheral neurotoxicity, and cancer in animals. Since the metabolites of these compounds are the same, ETBE may be similarly toxic.
2, 4-Dichlorophenoxyacetic (2, 4-D)
This was a very common herbicide that was a part of Agent Orange used by the United States during the Vietnam War to increase visibility for war planes by destroying plant undergrowth and crops. It is most commonly used in agriculture on genetically modified foods, and as a weed killer for lawns. Exposure to 2, 4-D via skin or oral ingestion is associated with neuritis, weakness, nausea, abdominal pain, headache, dizziness, peripheral neuropathy, stupor, seizures, brain damage and impaired reflexes. 2, 4-D is a known endocrine disruptor, and can block hormone distribution and cause glandular breakdown.
Diphenyl Phosphate
This is a metabolite of the organophosphate flame retardant triphenal phosphate (TPHP), which is used in plastics, electronic equipment, nail polish and resins. TPHP can cause endocrine disruption. Studies have also linked TPHP to reproductive developmental problems.
Acrylamide
Acrylamide can polymerize to form polyacrylamide. Polyacrylamide is used in many industrial processes such as plastics, food packaging, cosmetics, nail polish, dyes and treatment of drinking water. Food and cigarette smoke are also two major sources of exposure. Acrylamide has been found in foods like potato chips, French fries, and many others such as asparagus, potatoes, legumes, nuts, seeds, beef, eggs and fish. Asparagine, which is found in these foods can produce acrylamide when cooked at high temperature in the presence of sugars. High levels of acrylamide can elevate a patient’s risk of cancer. In addition, acrylamide is known to cause neurological damage.
Perchlorate
This chemical is used in the production of rocket fuel, missiles, fireworks, flare, explosives, fertilizers and bleach. Studies show that perchlorate is often found in water supplies. Many food sources are also contaminated with perchlorate. Perchlorate can disrupt the thyroid’s ability to produce hormones. The EPA has also labeled perchlorate a likely human carcinogen. Patients that are high in perchlorate can use a reverse osmosis water treatment system to remove the chemical from their water supply.
1,3 Butadiene
This is a chemical made from the processing of petroleum. It is often a colorless gas with a mild gasoline-like odor. Most of this chemical is used in the production of synthetic rubber. 1,3 Butadiene is a known carcinogen and has been linked to increased risk of cardiovascular disease. Individuals that come into contact with rubber, such as as car tires, could absorb 1,3 Butadiene through the skin. The increased used of old tires in the production of crumb rubber playgrounds and athletic fields is quite troubling because children and athletes may be exposed to toxic chemicals this way.
Propylene Oxide
This chemical is used in the production of plastics and is used as a fumigant. Propylene oxide is used to make polyester resins for textile and construction industries. It is also used in the preparation of lubricants, surfactants, and oil demulsifiers. It has been used as a food additive, an herbicide, a microbicide, an insecticide, a fungicide, and a miticide. Propylene oxide is a probable human carcinogen.
1-Bromopropane (1-BP)
1-Bromopropane is an organic solvent used for metal cleaning, foam gluing, and dry cleaning. Studies have shown that 1-BP is a neurotoxin as well as a reproductive toxin. Research indicates that exposure to 1-BP can cause sensory and motor deficits. Chronic exposure can lead to decreased cognitive function and impairment of the central nervous system. Acute exposure can lead to headaches.
Ethylene Oxide
Ethylene oxide is used in many different industries including agrochemical detergents, pharmaceuticals, and personal care products. Ethylene oxide is also used as a sterilizing agent on rubber, plastics and electronics. Chronic exposure to ethylene oxide has been determined to be mutagenic to humans. Multiple agencies have reported it as a carcinogen. Studies of people exposed to ethylene oxide show an increased incidence of breast cancer and leukemia. Caution is needed with ethylene oxide because it is odorless at toxic levels.
Acrylonitrile
Acrylonitrile is a colorless liquid with a pungent odor. It is used in the production of acrylic fibers, resins and rubber. Use of any of these products could lead to the exposure to acrylonitrile. Smoking tobacco and cigarettes is another potential exposure. Exposure to acrylonitrile can lead to headaches, nausea, dizziness, fatigue and chest pains. The European Union has classified acrylonitrile as a carcinogen.
Every day, we are exposed to hundreds of toxic chemicals through products like pharmaceuticals, pesticides, packaged foods, household products and environmental pollution. As we have become more exposed to chemical-laden products and to toxic chemicals in food, air, and water, we have been confronted with an accelerating rate of chronic illnesses like cancer, heart disease, chronic fatigue syndrome, chemical sensitivity, autism spectrum disorders, ADD/ADHD, autoimmune disorders, Parkinson’s disease and Alzheimer’s disease.
Blood requisition non-insurance
Complete blood work is helpful to rule out major sources of fatigue. One can see anemia, iron deficiency, B12 and/or folate deficiencies, thyroid imbalances, inflammatory markers, dietary fats, blood sugar imbalances, and some mineral imbalance. The great thing is Dr. Wells can see them before they actually occur!
Dr. Wells has a panel that she has used in her practice for many years. It is highly recommended that you have a consult with her for this. Dr. Wells understands that there are optimal ranges for these values, not just “normal” ranges. If you can tell your values are out “normal” it does not mean they are optimal!
Blood Panel includes:
Comprehensive Metabolic Panel (CMP 14)
Complete Blood Count (CBC) with Differential and Platelet Count
Vitamin D
25-Hydrocalciferol Insulin
Fasting Hemoglobin (HGB)
A1c
C-Reactive Protein (CRP) High Sensitivity (Cardiac)
Lipid Panel with LDL/HDL Ratio Ferritin
Serum Thyroxine
Free (T4, Free)
Triiodothyronine
Free (T3, Free)
TSH Reverse T3
Iron
Serum Sedimentation Rate (ESR)
Westergren Magnesium
RBC
Gastrointestinal Comprehensive Tool Analysis
Great health includes proper digestion, assimilation of nutrients, ability to ward off pathogens and timely elimination of waste! One part cannot be left out! Poor digestion and malabsorption of vital nutrients can contribute to fatigue, chronic diseases, poor immune status and nutritional deficiencies.
Impairment of the intestinal system can lead to the development of food allergies, systemic illnesses, autoimmune disease, and toxic overload from substances that are usually kept in the confines of the battle for elimination. With the results of this stool analysis you receive a comprehensive research based guide on how to eliminate pathogens, restore proper digestion and promote healing.
The Gastrointestinal Comprehensive Stool Analysis answers the following questions:
Do I have good or bad bacteria or yeast?
The Comprehensive Stool Analysis is a tool that allows one to see the actual numbers of good and bad bacteria as well as yeast or candida. There are many strains or species of each, which are identified in this analysis. Incredibly important is the culture and sensitivity testing that identifies which natural medicines or drugs kill your specific species of pathogen.
Am I digesting my food properly?
The levels of undigested food such as fat, muscle, vegetables and carbohydrates is determined. Also measured are the levels of pancreatic enzymes.
Do I have an inflamed bowel?
Chronic inflammation can go undetected and cause low grade problems that turn into bigger life threatening issues if left unchecked. If inflammation is found, changes in diet and supplementation can turn things around quickly. One can also use other testing methods, such as food testing, to find the source of the information so it doesn’t return. This testing can determine if you have inflammatory bowel vs irritable bowel.
Is the immune system in my GI tract working?
In addition, the immune system marker secretory IgA is checked, a valuable assessment tool. Secretory IgA prevents binding of pathogenic material to the mucosa of the gastrointestinal tract, preventing damage.
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Complete Adrenal Saliva Kit
The adrenal hormones are DHEA and cortisol. These hormones will give us important information about deficiencies, excesses and your daily patterns.
DHEA
An important adrenal gland hormone for energy production and blood sugar balance. DHEA is a precursor to other hormones, such as testosterone.
Cortisol
Your waking day hormone (highest in the morning and lowest at night). It is necessary for energy production, blood sugar metabolism, anti-inflammatory effects and stress response. There are four phases of adrenal fatigue determined by the pattern of the four saliva test times – morning, noon, evening and night. Your cortisol level is compared to the optimal range.